Abstract
Bioassay-guided fractionation of an organic extract from the leaves of Cupaniopsis macropetala resulted in the isolation of a new alkaloid, galloyl tyramine ( 1), together with the known flavonoid glycoside quercitrin ( 2). The structure of 1 was determined following 1D and 2D NMR, IR, UV, and MS data analysis. Compounds 1 and 2 displayed IC 50 values of 161 and 25 microM, respectively, in a Pim2 enzyme assay.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Gallic Acid / analogs & derivatives*
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Gallic Acid / chemistry
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Gallic Acid / isolation & purification
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Humans
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Molecular Structure
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Papua New Guinea
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Plant Leaves / chemistry
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Plants, Medicinal / chemistry*
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Protein Serine-Threonine Kinases / antagonists & inhibitors*
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Proto-Oncogene Proteins / antagonists & inhibitors*
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Quercetin / analogs & derivatives*
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Quercetin / chemistry
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Quercetin / isolation & purification
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Quercetin / pharmacology
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Sapindaceae / chemistry*
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Tyramine / analogs & derivatives*
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Tyramine / chemistry
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Tyramine / isolation & purification
Substances
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PIM2 protein, human
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Proto-Oncogene Proteins
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galloyl tyramine
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quercitrin
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Gallic Acid
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Quercetin
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Protein Serine-Threonine Kinases
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Tyramine